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Entyvio and the immune system

Entyvio works differently than other biologics by focusing specifically on the GI tract. It prevents an excess of white blood cells from entering into the GI tract.

Does it mean that the chances of getting an infection while taking it are smaller than when taking other types of biologics? The Entyvio website gives the regular warning under the safety information:

ENTYVIO may increase your risk of getting a serious infection. Before receiving and during treatment with ENTYVIO, tell your healthcare provider if you think you have an infection or symptoms of an infection, such as fever, chills, muscle aches, cough, shortness of breath, runny nose, sore throat, red or painful skin or sores on your body, tiredness, or pain during urination.
Since it works by only targeting the immune system response in the GI tract, does it also lower the overall ability of the immune system to fight infections like the other biologics?
 
I don't have all of the answers. But antidotally, I have gotten sick much less on Entyvio than I had on Humira. (I am a teacher and am exposed to things a lot.) Entyvio has changed my life in the 7 months I've been on it. I'm not sure about risk of more serious illnesses. I hope you figure out what works best for you soon.
 
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