@Scipio sorry to ask but I wonder if I could ask your advice on my post in this forum? My G.I asked me.. "what biologic do you want to try first?"
I have a lot of concerns about systematic side effects or even bad reactions some people have to biologics the first time.
I think perhaps Skyrizi or Entyvio is considered both the safest and most effective. I've had two G.Is I've seen in person tell me something like that.
My personal situation is I need to travel outside of the country.. sometimes for months at a time. I'm trying to see how I could get started on biologics and then continue with it while I'm overseas but most likely I would need to obtain the biologics in the U.S due to cost.
It took me a very long time to understand this and was stopping me from starting treatment. Another issue is the reported efficiency. For example Entyvio shows only 32% of patients achieving remission at 1 year vs 16% on placebo. Given the perceived risk and a small improvement over placebo explains why many patients decide not to go ahead. What the stats don't show is the possibility of a reduction of symptoms (not a full remission) that makes it worthwhile.All the talk of side effects for biologics is IMO a bit overblown. The way I sum it up is the greatest health risk to Crohn's patients is not the risk of side effects from biologic drugs. The greatest health risk to Crohn's patients is the constant and lasting damage to the gut due to untreated or poorly controlled Crohn's disease.