http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3800670/
Now this part really got my attention:
"Human research has shown that patients with mutations in Crohn's disease genes such as nucleotide binding oligomerization domain 2 (NOD2) [33] and autophagy related protein 16L-1 (ATG16L1) [34] have decreased numbers of the Firmicutes species of bacteria Faecalibacterium prausnitzii and Roseburia intestinalis in their ileum [35]. This decrease in commensal bacteria is associated with a proportional increase in the pathogenic adherent invasive Escherichia coli and Salmonella typhimurium [36, 37]. The inability of Faecalibacterium and Roseburia to survive in the intestinal microbiome of patients with Crohn's disease deprives these patients of bacteria which produce short chain fatty acids (SCFA) used as nutrition and energy for colonocytes [38]. Decreased SCFA leads to increased colonocyte death, increased cell turnover and may explain in part the 3.2-fold higher lifetime risk of colorectal cancer observed in Crohn's when compared to general population [39, 40]. "
I asked my GI at the last scope if he could sequence my tissue from the ilieum to see what bacteria is present there. He just answered that they don´t do that...
Now this part really got my attention:
"Human research has shown that patients with mutations in Crohn's disease genes such as nucleotide binding oligomerization domain 2 (NOD2) [33] and autophagy related protein 16L-1 (ATG16L1) [34] have decreased numbers of the Firmicutes species of bacteria Faecalibacterium prausnitzii and Roseburia intestinalis in their ileum [35]. This decrease in commensal bacteria is associated with a proportional increase in the pathogenic adherent invasive Escherichia coli and Salmonella typhimurium [36, 37]. The inability of Faecalibacterium and Roseburia to survive in the intestinal microbiome of patients with Crohn's disease deprives these patients of bacteria which produce short chain fatty acids (SCFA) used as nutrition and energy for colonocytes [38]. Decreased SCFA leads to increased colonocyte death, increased cell turnover and may explain in part the 3.2-fold higher lifetime risk of colorectal cancer observed in Crohn's when compared to general population [39, 40]. "
I asked my GI at the last scope if he could sequence my tissue from the ilieum to see what bacteria is present there. He just answered that they don´t do that...