Just started talking with my Dr about trying Entyvio because I have already been through Remade (two years of working then nothing), Stelara (apparently never worked for me) and, of course, all the other early diagnosis fails with Budesonide, etc. I have Crohn's only in my terminal ileum and it has not spread but it is causing a stricture now. Any advice, information or what to expect from Entyvio would be helpful. Feeling a little discouraged and fatalistic about even trying it after the other biologics don't seem to work. I read a little here where people said it isn't very effective for Crohn's in ileum so that was even more discouraging. If this doesn't work don't even know what is left for me other than steroids. I may need surgery anyway due to stricture and assume I'll still need medication even if they cut out where inflammation is now. If none of these medications help seems like I'm moving down the slippery slope of everything getting even worse.