• Welcome to Crohn's Forum, a support group for people with all forms of IBD. While this community is not a substitute for doctor's advice and we cannot treat or diagnose, we find being able to communicate with others who have IBD is invaluable as we navigate our struggles and celebrate our successes. We invite you to join us.

First JAK Inhibitor Approved by FDA for Treatment of Crohn's


Well-known member
San Diego

A new class of drugs for Crohn's and thus new treatment options. Due to increased risk of blood clots and cancer, use of Rinvoq is to restricted those Crohn's patients who have already flunked therapy with anti-TNFs such as Remicade or Humira.
Last edited:
This seems to be the most unsafe drug ever to get an approval for the treatment of CD.

I wouldn’t consider using jak inhibitors unless I really had no other choice.


Well-known member
I remember getting asked to join a trial for it, thankfully i refused
Good for you. I hope people realize the danger of these drugs and their lack of effectiveness in crohn's disease. There is enormous financial pressure on companies due to anti-TNF patents expiring and cheaper biosimilar replacing them.

I warned multiple times about them: