When I get Remicade, they make me take some Benadryl and Tylenol to prevent an allergic reaction. Then they put the IV in and draw some blood and flush the line with a little syringe of saline. They drip in some steroid, and THEN actually get on with the Remicade. And after all the Remicade is in, they flush the line with more saline.For me, the little bit of saline at the beginning was always colder than the Remicade (which is at room temp) and I could taste/smell it. When they increase the rate of the infusion, you can kind of feel it pumping into your veins. It's a little gross, but definitely bearable. And if you ask for a warm blanket or a hot pack, you won't feel the colder liquid entering your arm.
And there's usually a chair or two in the little infusion cubicle so someone can sit with you! If there are no chairs, I'm sure you can always ask and they'll find you one.
Good luck! Let us know how it goes.