Its important, but they are just signaling molecules for the inflammatory/immune response. Thing is, lots of things influence this pge2, the research is needed, but I don't think there is anything groundbreaking here. And many other genetic studies will come up with similar conclusions, the same risk genes found in crohn's patients can be found in people that never develop the disease at all, this is why the microbiome should get more focus and actually is getting more focus now. There really is a reason so many private corporations are investing in microbiome startups, it's a really big deal. my guess is these gene associations are no more important to a susceptibility to inflammation as the genes that determine your muscle size make one person more susceptible for fatigue in a bout of resistance exercise.