Apologize for length and posted this also on Imuran discussion- 57 yr old male. Diagnosed w Crohns for 20yrs (1999). Otherwise great health and live a very active lifestyle. Prescribed Pentasa, been on ever since. Only symptom for 16 yrs was uncomfortable cramping 12 hr period maybe 2 or 3 times a year. Very manageable. In 2016 the cramping generally went away but started having lots of gastric noise and fatigue often with a slow period weight loss. GI recommended CT as not had any test since 1999. Test revealed had developed a fistula above crohns area in small intestine. Got second opinion from major university specialist. Was told should have surgery and then go on a biologic. As I felt generally good I freaked out over this. Decided I not doing any of this until I felt bad enough to go w surgery then hardcore drug. Again all manageable last 4 yrs. First of March last month developed a strange sharp pain in lower right of abdomen. Went in another Ct. Found I had abscess. General Physician put me in hospital that day. Several days in to drain then on antibiotics for several weeks. General, GI and Surgeon recommended surgery. Went in they removed 12 inches of bad area. Healed very fast last in few weeks and feeling fantastic now. No symptoms and eating like crazy. Last week GI I recommended remicade/Humira. I had same concerns about biologic and worried about Covid 19 effects while on drug (my job requires face to face with people). GI reversed and suggested Imuran would be better as I doing well so far and Imuran not as immune altering along w easy to take. Was excited after hearing this but surfing the net it appears side effects just as bad as Remicade or Humira. I have just as much fear based on what I am reading. I feel great but dont want to stick my head in the sand and ignore potential issues. Greatly appreciate any thoughts or recommendations. Thanks so much!