I've been on it for five years, the last two in conjunction with Remicade. In the last year, I've had recurring colds, strep throat, oral thrush, yeast infections. Two months ago my peripheral neuropathy came back, then my hair started falling out. Not sure if those are related. My GI has finally decided to take me off Imuran, since it's causing so much trouble. He didn't say how long it would be in my system. This is a relief, but also scary. I'm hoping the Remicade will keep me in remission.