I've been on Amitriptyline 25 mg for about a year and a half now. I was initially put on it because Entocort gave me chronic, constant headaches. Amitriptyline is very good at preventing headaches, and within a short time of starting it, the Entocort headaches ceased. I stayed on Amitriptyline even after stopping Entocort, because it prevents my migraines pretty well too. I still have the ocassional migraine but not nearly as frequently as I used to. Amitriptyline knocks me out at night too and helps me sleep (drowsiness is the only side effect I've noticed - I take it at bedtime so it's not an issue at all). My GI told me that Amitriptyline can help calm the guts as well and help ease pain, but honestly I never noticed any difference there. From what I've read, Amitriptyline works better in that regard for IBS than IBD. I'm still not fully diagnosed, but both my GI and GP have unofficially said that I've got IBD. Anyway, overall I'm happy on Amitriptyline although it does nothing for my guts.