• Welcome to Crohn's Forum, a support group for people with all forms of IBD. While this community is not a substitute for doctor's advice and we cannot treat or diagnose, we find being able to communicate with others who have IBD is invaluable as we navigate our struggles and celebrate our successes. We invite you to join us.

Humira Was working, now its not

I was diagnosed January 2017, resection in June, started Humira at the end of September. I have gained about 30 pounds and everything was going great. I have not had a solid bowel movement(Just D) in the last two weeks. I do not really have any other symptoms except for slight nausea right before I go to the bathroom. No pain. Could it be that Humira is not working for me anymore? I am getting blood work done tomorrow and I do have a doctor's appointment next week. I just wanted to hear what other may have to say. IBD is so complicated and different for everyone. Thanks for hearing me out.
I was on the same situation and the doctor increased the frequency to every week from 2 times a month. A couple of months later it was not working again. Had the blood test to detect antibodies and I had them. So tried Entyvio for 7 infusions and did not work at all. Was on Remicade for two years, then it stopped working, the doctor doubled the dose. After a couple of months later was not working again.

Moral of the story: once you develop antibodies it does not matter how you increase the dose, eventually it will stop working.

Now I have been six months on Stelara and it is working.