I started taking Humira in February. I haven't seen any results. If anything, they are worse. Even more, I haven't been this fatigued in my entire life. I am physically exhausted everyday. I had just stopped a five week prednisone taper then as well but was put back on it a couple of weeks ago. I am also on Flagyl. I should also say that I don't have a thyroid so that could also be part of this. Does anyone else have fatigue in regards to taking the Humira or do you guys think its just not working and my Crohn's is getting worse?