Il-27

[Skinsfan1229]

IL-23 and IL-27

http://www.wwaytv3.com/Global/story.asp?S=5595785&nav=menu70_8



The IL-23 pathway is important in the body's infection defense system, Cho said. IBD appears to be caused by an abnormal reaction against the very high concentration of bacteria normally found in the intestines. Thus, it might be possible "to block IL-23 function in a way that markedly reduces disease," she said.

 

[Skinsfan1229]

http://www.sciencedaily.com/releases/2006/08/060821135156.htm


"There are many immune-mediated diseases with many different causes, but the type of cells that IL-27 inhibits are a major part of the pathway of cellular signals that lead to inflammation," said Christopher Hunter, professor in Penn Vet's Department of Pathobiology. "Our findings indicate that IL-27 is a prominent factor that helps keep the immune system under control."

To understand the role of IL-27 in chronic inflammation, Hunter and his colleagues at the Ludwig Institute in Melbourne, Amgen and the NIH studied mice engineered to lack the receptor that enables IL-27 to function in normal mice. When infected with the parasite Toxoplasma gondii, which causes toxoplasmosis, the mice developed severe brain inflammation that was caused by helper T cells, a type of white blood cell that activates and directs portions of the immune system. Without the ability of IL-27 to regulate the immune system, however, the response to the infection in the brain goes out of control.

 

[GNC Crohn's Man]

Ok read article so the found the big off switch on the circuit breaker.... I wonder if TNF-a is one of the switches of this paticuluar circuit breaker...

I probably could find out but I don't feel like reading medical texts atm....

I wonder how similar it is to TNF-alpha (Tumer Nucrusis Factor Alpha) in humans because the remicade and humira already work by blocking those except you only have to worry about getting a lung infection and dieing when you take those.... I really wouldn't won't to be killed by a cold or the flu if it just happened to infect the brain because my body couldn't fight off the infection...

I would much rather die from nice happy tubercolisis or phenomeuna...

 

[Skinsfan1229]

I knew about the TNF-a being takin out of the blood stream by remicade, I wasnt sure about humira.

This was just pretty much an article I came across that I havent read yet, or seen anything about pretty much so I decided to make a thread just for the 'useless' knowledge of crohns.