Hey all--I've been on Imuran for about 3 months now and it's mostly doing OK. I've had some tiredness and some arthritic pain, but recently I've noticed some pronounced swelling in my right knee. Has anyone else had that problem? I saw my GI last week and she said to watch it and let her know if it doesn't go away. It's not getting any worse or any better, it just seemed to come on suddenly one night last week and hasn't gone away. At first I thought it might be some tendonitis--since I'm prone to that in my knees--but I haven't done anything that usually brings that on, and then I was reading the "serious side effects" section of my RX when I picked up a refill and swelling of joints is on there. Anyone else have this type of swelling in one joint with Imuran?