I am currently trying to decide between 6-MP and Methotrexate (which is also in that middle class of drugs), in addition to the Humira I have been on for a month now. My pharmacist stated to me that 6-MP has a lot more side effects but seems to work well in patients with Crohn's, along with a lot of other illnesses. My new GI much prefers 6-MP over methotrexate, but my PCP, pharmacist, and neurologist have stated that it is a very old and well proven to work drug and it could help with some numbness and tingling I have in places. I have not asked about Imuran since my old GI stated that it would not be a good idea for me and my new GI does not like to use it. I have heard others speak very well of it, though. Sorry that I am of little to no help and I hope that you find what works best for you. Some combos of medications work well for some but don't work for others. I hate that Crohn's is such a game of pick and choose and see if it works.