Ds started humira at age 9
Once every two weeks
Then switched to every 10 days after a year
Then every week after another year or so and finally every 5 days
He was able to be in humira for over 5 years
No increase in risk
Risk is simply from taking the med
No issues in 5 years
He was also on mtx (due to juvenile arthritis as well as crohns )
He had to have minor surgery (non crohns ) and held humira which made it stop working when he restarted
Switched to Stelara at 14 (almost 3 years ago )
so for him biologics (even at higherfrequency has not presented a problem
Fwiw he is on Stelara 90 mg every 4 weeks and has been for 2.5 years