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Inflammation-driven bacterial dysbios.


Well-known member
The chicken or egg problem.

(1) Does dysbiosis result in inflammation.
(2) Or is dybiosis the result of inflammation.

This is an important question. Because if the dysbiosis is secondary to inflammation, no amount of modulating the microbiome will be beneficial in crohn's disease.

It is also important because billions are spent on microbiome research, including a lot of money coming from funds for crohn's disease.

So far, all the attempts to modulate the microbiome (probiotics, prebiotics, fecal transplants) in crohn's disease patients, have failed.

It is interesting that in intestinal diseases where a pathogen causes inflammation, dysbiosis usually follows, when inflammation subsides, so does dysbiosis. Dysbiosis was not behind the inflammation, it was secondary to the infection.