I'm cautiously optimistic. The constant burning pain and fullness that I wasn't even aware of have dissipated. The urgency that caused goosebumps and a lot of running and some oops is gone. I hate to get too excited but it feels good to feel a little better. My dr's nurse only made me take one shot and when I read the Cimzia site I called back and she had me take the other shot. I'm guessing I take 2 shots for my next dose too. I find it very convenient not to have to take something three times a day that doesn't work on me anyway. This is the first thing that has even touched it.