I started LDN last March. I started at 4.5 mg which was too high for me. It made me tired and my d wasnt good. The doctor lowered it to 3 mg. I've been fine since. No D at all. My fistulas aren't healing though as I hoped. In fact I'm having an awful time with them. The LDN is really good at stopping the D for me anyway. Just watch if you feel bad it might be your taking a higher dose than what you need. Bree