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LDN and L Glutamine

Hello,

Amongst other supplements, I have been taking L Glutamine. I have been told by an "expert" that you should not take L Glutamine along with LDN as it would work to oppose the intended action of LDN. Can anyone throw any light on this?

Should I stop taking the L Glutamine?

Sally
 

Kev

Senior Member
I have no knowledge of this... did your expert provide any 'sources' or 'references' for this?

I would double check with places like lowdosenaltrexone.org....

Problem with LDN is it is 'relatively' new, and a lot of the so called 'experts' really aren't. I REFUSE to let anyone point to me as having expertise. I'm just a IBD sufferer who has been taking it (LDN) since 2007.

Now, if you can't get a definitive answer on L-Glutamine and LDN, then you may have to be your own ... Guinea Pig??? ... Lab Rat???. If the LDN HAS demonstrated that it IS working for you... (probably not the case, else why write?) then leave everything alone. If it hasn't... and you are 'waiting' for a result... a sign... and are closing in on 2 months or so... AND you can 'safely' skip or minimize your L-glutamine.. you might want to put it to the test....

Wish I had a better response to offer... However, this may be a case where you have to be the 'groundbreaker'... and someday someone will come to you searching for advice..
 
Hi Kev,

Sorry for delay in responding. No, she has a lot of letters after her name and is the technical expert for Cytoplan Limited. I will respond to her email and ask her where her information comes from.

I hadn't noticed any difference with taking L Glutamine but it purports to heal the gut more quickly. As for the LDN, my abdomen is still sore to the touch, so I guess that I'm not in remission yet. However I am mainly having normal BMs and my blood results are all within normal range now, apart from my liver function test but my consultant thinks that is the LDN.

I was really just wondering whether it would be better to stop the l Glutamine in view of what she said. However, I don't want to make things any worse, or else my consultant won't want me continuing with the LDN as he is quite anti. It was just my powers of feminine persuasion that caused him to relent!

Inam also concerned about the LDN in that I am now on my third lot of 60 capsules. Each time, the expiry date shows October of this year. I asked my consultant to as for freshly compounded LDN for the last repeat prescription - which he did. However, when I picked it up, it had the same expiry date as the last two prescriptions. I think that is highly suspect. I mentioned it to my consultant and he shrugged and said we'll never know.

The hospital send it off to a specialist company - Martindales - who I think are also in the USA? Theynwon'tvtalk to the public, somI asked the hospital pharmacy. They said it was freshly compounded, but how are they to know?

Oh we'll - I should presumably be in less and less pain as time goes on - but my three months on LDN is up on 18th March. Do you remember how you felt after the three month period had expired?

Best get on with some work now!

Kind regards,

Sally
 

Kev

Senior Member
Sally

Stopping the disease AND stopping the pain.... you MAY not get both. My disease is stopped dead in its tracks... but I live in daily pain. Scar tissue... LDN won't change that. Soooooo, if you are 'estimating' where you are in the recovery process by the amount of pain you are feeling.... it may be totally un-related. If BM's are better, and other symptoms.... diarrhea, gas, appetite... are improved... and bloodwork looks good, then I would think everything is coming along quite nicely. As for pain.... wait and see.

If you can't be certain of the freshness of the compound (a valid concern) your options are to accept what 'they' tell you UNLESS/UNTIL your symptoms start to deteriorate. OR get the 50 mg Naltexone pills, some distilled water and make your own compound. OK?

I guess.... and it is not much to offer.... the only thing to do is keep doing what you are doing... and hope for the best. If it's working, then don't "FIX" it.

Look.... I seem to recall that... back in the early days... when things started going good for a change.... it was an emotional rollercoaster... waiting to see if it was going to work.. then periods when I wasn't sure whether it was working or not... then whether it would continue to work... From that experience... my advice would be... take it one day at a time... fingers crossed.
 
Hi Kev,

Hi Kev,

Thanks for posting. So, sorry to be intimate, but if you press the Crohns area, does it hurt? I find that sometimes it also feels enlarged as well as painful.

If I get the naltrexone pills, how would I know they are OK and in date? Or does freshly compounded mean crushing pills. I'm not sure i would know how to get 4.5 mg in a capsule with the filler. Sounds complicated to me! Or am I being dumb? Maybe you shouldn't answer that!

All the best,

Sally
 

Kev

Senior Member
Hi Sally

OK, ... my 'scar' tissue... actual bands of scar material running criss cross inside my GI tract. Everything that passes through me has to pass through, around, over or under my scar tissue. So, for want of a more polite way of putting it... things tend to logjam inside me. The pressure of that causes pain... then things break free... flow thru... that causes me pain... and after it has passed... either material or gas... well, the pain is very REAL.
My abdomen can get extremely rigid... undulate... and make phenomenal noises during these bouts.. and apparently I curse, swear, moan and groan in my sleep due to it.

Now, as for making homemade LDN... you'd need to consult the lowdosenaltrexone.org site... My understanding is you take a 50mg pill, dissolve it in sterile water.. say 50ml
if you then take a 5ml eye dropper full... you should have 5mg of Naltrexone, close enough to be 4.5mg equivalent. Now, PLEASE don't us my memory version of how it is done. Go to the LDN website... or consult with others who make their own. Of course, the freshness done this way is another matter... Essentially you could make a 10 day dose from each pill... but how long it would stay strong in a liquid, I wouldn't hazard a guess.
 
Hi Kev,
Thank you. I will look into that. Thank you also for sharing your "intimate" details. Luckily, or unluckily, I have no one to tell me whether I moan and groan in my sleep - don't think I do at the moment, though used to wake up with the pain regularly when I had the abscess.

Anyway, onwards and upwards, and thanks again for your reply, which is much appreciated.

Sally
 

Kev

Senior Member
Well, I think it is important to point out that abscesses, fissures, fistulas... these can heal. But once formed, scar tissue is pretty much a permanent condition. But it is livable. I get thru my 'day', grin and bear it (OK, occasionally 'grimace')... stiff upper lip and all that rot.

But, at night, with no one conscious at the 'self edit' controls, I tell the whole world (or at least anyone within earshot) EXACTLY what I think of these pains. Just food for thought.
 
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