Hi all I am very new to the site so I'm sorry in advance if there is already a thread regarding this. I have a perineal fistula that developed January '10 right after I had my son. I did Remicade for a year which did work wonders but then switched to Humira for the convenience. I went off the Humira around Oct 2012 because it didn't seem to be working. I did a round of Remicade in November but had a reaction to it and then have not been able to try again due to BP problems and ear infections. My question is has anyone had a perineal fistula heal with LDN. I am so worried about the side effects of the Remicade and Humira that I think about it all the time. From what I have been able to find LDN seems pretty harmless and some people have said cheaper? I have a seton in now which doesn't really bother me but I am over the drainage and panty liners that I have to wear for it. Any info or advice would be GREATLY appreciated.