What is the best pain reliever for horrible pain in legs due to prendisone? I am having terrible, terrible pain in my legs at night and in the morning, and I guess it is a side effect of taking Prednisone for Crohn's. I've been on it for 6 weeks now, and they have me on high doses, just starting to taper and it's killing me. I have been taking Tylenlol, is there something better that anybody might know of? Thanks!