I have been on methtrexate weekly injections of 25mg since July and it has been fine other than the last 4/5 weeks I have had an outbreak if spots on my face . They are big red and painful, they die down for a day or 2 and they become painful again without ever properly going away. I've never suffered badly with spots even as a teenager but i seem to be getting more and more. Has anybody else experienced this on methtrexate? It's getting annoying now and everything I try fails to clear them up! I'm assuming it's the methotrexate or at least linked to it, I was on prednisolone aswell but tapered off it and have been off it for 2 weeks now.