My son has been on methotrexate now for about 1year. He always feels a little more tired a day or two after, but lately he has been getting very sick the night of taking it and for a couple of days after. Has anyone else been ok taking the med and then it started not agreeing with you? We saw the doctor on Friday and she suggested an hour before taking methotrexate to take an anti nausea medication, and still he was up vomitting. Any thoughts or suggestions??