Hi I'd like to share my experience and some infos about methotrexate, which i took for about year, by weekly injections (20mg).
I was lucky enough methotrexate didnt cause me any (known) side effects, well except a bit of hair loss at the beginning.
Methotrexate in the context of an IBD, could be better absorbed via Injection route. I have a pharmacist who works in team with my GI and who specializes in IBD research and treatment. She insisted I got the injection. In the context of arthritic disease (i.e Rhuematoid Arthritis), pill version is the norm. Injections are not painful and are easy to make. They are not fun of course, but ok. I was pretty nervous the first few times, but after, its very easy.
It is important a trained nurse should help for first injection, as there are many little details. If I remember correct, it is also said injections have less possible gastro-intestinal side effects.
There are some variations in methotrexate injection list of ingredients depending on which company produces it. If you would like to avoid extra conservatives inside, its possible to call your pharmacy and inquire about ingredient in the composition of the drug and possible options. I did that and I had my injection delivered every week at home instead of once a month, for the same price, minus some of the conservatives! This initiative was a personal choice and not a recommendation from a specialist. Its also possible to make your own seringes right from the vials to avoid extra conservatives, but because of particules that can be launched in the air around during manipulation and inhaled by the rest of the family or pets, pharmacists will prefer we have the seringes prepared in a pharmacy where technicians use protective suit and ventilation equipment! I found the best way for me was to have it made magistrale by my pharmacy and delivered everyweek.
also regarding Folic acid, which should always be taken during treatment with methotrexate, there are different dosing protocols. my specialized IBD pharmacist clearly mentionned not to take Folic acid the day BEFORE and the DAY of methotrexate. It should be taken depending on dosing prescribed, the day after or remaining days of the week, if on a low dose continuous daily schedule.
I hope this help.
Im wishing you a good journey on methotrexate, really feel sorry for Trev who has had a really bad experience. Unfortunately, methotrexate has prouved to be ineffective in my case as my recto-colitis is flaring right now. Im back on purinethol for a 3rd time, hoping blood counts will be great this time around.