Hi everyone, I started on Methotrexate last week (second dose today) and I have been feeling really cold (like from the inside out) and was really aching during the night of the first dose. Anyone else felt like this or am I imagining it. I am usually quite warm and enjoy 'personal summers' (ladies of a certain age will know what I mean !) Not due for blood test till end of next week and see consultant week after that.