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Hey guys

After a recent visit to my doctor, I was prescribed Mezavant to start taking as I taper away my prednisone (currently 35mg)

On prednisone alone, I feel relatively fine (besides irritability at the end of day) with only one bowel movement in the morning.

For the first 3 days I have been on 4.8g mezavant, I have had on all three days a 2 hour period where I'm forced to lock myself in the bathroom for a horribly painful nauseating bloody bowel movement. It's torture.

My pharmacist recommended I lower my dosage to 1.2g to let my body adjust to it. Even on this dose, I get woken up in the morning by very painful cramps and proceed to take a 20 min bowel movement ( that's how long it takes me to feel "empty"). I also feel uncharacteristically exhausted during the day.

Is this all part of the process? Or do I suffer from the rare acute intolerance syndrome?

I have a GI appointment this wednesday, and I'm just about to quit mezavant completely until then.
I'm on 3 caps of Mezavant (want to say that's 9 g total but don't quote me on that). Since January-ish. Was on Asacol previously, couple years back.

I seem to do fine on both, although question if they actually do much of anything as far as help.

Some people swear by Pentasa/Asacol/Mezavant and others, like you, report serious side-effects or intolerance.

I'd not be taking anything that I react that violently to, especially if I were trying to taper on Pred. Talk to your GI and hopefully they'll have a plan for you!

Best of luck.
I would lean towards saying it is NOT part of the process. I have never heard of it being a drug you need to taper up. I started on the full 4.8g. You may very well be intolerant to it. Some people are. I wouldn't blame you for stopping until your appt. There is really no risk if its not help you anyway.