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More info peeps

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plagueius

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more info peeps

Is Crohn's disease caused by a mycobacterium? Comparisons with leprosy, tuberculosis, and Johne's disease

Robert J Greensteina, Corresponding Author Contact Information, E-mail The Corresponding Author

aConsultant in the Department of Surgery and Director of the Laboratory of Molecular Surgical Research, VA Medical Center, Bronx, NY, USA


Available online 29 July 2003.


Summary

Although Crohn's disease is considered to be autoimmune in origin, there is increasing evidence that it may have an infectious cause. The most plausible candidate is Mycobacterium avium subspecies paratuberculosis (MAP). Intriguingly, Koch's postulates may have been fulfilled for MAP and Crohn's disease, even though they still have not been met for Mycobacterium leprae and leprosy. In animals MAP causes Johne's disease, a chronic wasting intestinal diarrhoeal disease evocative of Crohn's disease. Johne's disease occurs in wild and domesticated animals, including dairy herds. Viable MAP is found in human and cow milk, and is not reliably killed by standard pasteurisation. MAP is ubiquitous in the environment including in potable water. Since cell-wall-deficient MAP usually cannot be identified by Ziehl-Neelsen staining, identification of MAP in human beings requires culture or detection of MAP DNA or RNA. If infectious in origin, Crohn's disease should be curable with appropriate antibiotics. Many studies that argue against a causative role for MAP in Crohn's disease have used antibiotics that are inactive against MAP. However, trials that include macrolide antibiotics indicate that a cure for Crohn's disease is possible. The necessary length of therapy remains to be determined. Mycobacterial diseases have protean clinical manifestations, as does Crohn's disease. The necessity of stratifying Crohn's disease into two clinical manifestations (perforating and non-perforating) when interpreting the results of antibiotic therapy is discussed. Rational studies to evaluate appropriate therapies to cure Crohn's disease are proposed.
 
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Skinsfan1229

Guest
Alright I so you posted before, there is under another part of the forum which I will look for in a moment about MAP.

I believe an easy to understand website is www.crohns.org and http://www.nacc.org.uk/downloads/MAPVer9.pdf (which I doesnt agree with MAP causing or inflicting Crohns Disease, but the first website does support it, both proived funding its nice to check them out, the first is more bulleted with key points, with the second really easy to understand moree then if you stray awaay from the bullets on the first)

Good Luck. There are a few about this recently, like within the past 2 or 3 days you should look for, and either me or Ruth started it....so look for our Login.

Here's something new.

http://www.ccfa.org/about/press/il23?msource=HQ0710DMENWS&tr=y&auid=2105205
 
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