Have had Crohn's since I was probably 14 and am 50 now. I have been on prednisone for years on and off, have tried Remicadee, my body didn't absorb it, tried Humira, same story. Now I'm trying Cimzia and I don't feel like that's doing anything. I have a fistula from my small bowel to my colon so i'm not absorbing much of anything so I weigh 80 lbs. I have no idea what the next step should be.