I am a 39 y/o female and was just diagnosed with Crohn's. I have had digestive problems for about 7 years, but after going to many many doctors, they just got to the root of the problem which is that I have Crohn's. They have me on Pentasa 1000mg 4X a day. Before I was diagnosed through a colonoscopy, I only rarely felt nauseous and really didn't have any other problems other than occasional constipation or diarrhea and some light bleeding during bowel movements. I have had surgery for a fistula and hemorrhoid surgery. I am tired a lot with no energy and just thought maybe I had gotten lazy. Now my concern is that since I have been diagnosed, 3 weeks ago, and started taking the medication. I am nauseous every day towards the evening, ulcers in my mouth and I have these sore knots on my lower legs. Does anyone else have that problem? I asked my doctor and she said that was because of the Crohn's and has nothing to do with the medicine. I just find it hard to believe considering I have never had an ulcer in my mouth and knots on my legs. I am just reaching out to anyone who has the same issues as me. Thank you.