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New type of treatments

Crohn’s disease can be treated with plantain fiber

By admin on August 9th, 2012

Peter Laing, Director of Research and Development, Provexis, said: In collaboration with the CRB, we hope that this new medical food containing plantain soluble fiber, can help stop the progression of the disease and keep coming back.University of Liverpool Professor, Jon Rhodes, the Liverpool Biomedical Research Centre , said: Crohn’s disease affects people from all over the world, but is much more widespread in developed countries, where a diet of foods rich and treated fiber is common. There was a rapid increase in the incidence of the disease in Japan, for example, who is now a system of Western processed foods. Dietary factors and the greater number of E.

The sticky E. coli are able to penetrate the intestinal wall by special cells called M cells which act as guardians of the lymphatic system. In patients with Crohn’s disease leads to chronic inflammation of the intestine. Scientists have found that plantain soluble fiber prevented the absorption and transport of E. M.cells coli. They compared these results with tests on polysorbate-80 – a fat emulsifier used in processed foods to bind the ingredients together.

Scientists are currently conducting clinical trials to test whether a medical food containing plantain fibers could keep Crohn’s patients in remission.

Crohn’s is a condition that affects one in 800 people in the UK and causes chronic intestinal inflammation, resulting in pain and bleeding. Researchers working with the biotechnology company, Provexis, to test a product new plantain based food that may treat patients with the disease.

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Barry Campbell, University of Translational Medicine Institute, said: This research shows that the different components of the diet can have powerful effects on the movement of bacteria in the gut, we have known for some time the general health benefits eating broccoli and plantain. Both are rich in vitamins and minerals, but until now we have not figured out how you can strengthen the body’s natural defenses against infection common in patients with Crohn’s.

Priligy .

Our work suggests that it may be important for patients with this condition to eat healthy and limit the consumption of processed foods.
Here is the complete study.


If I had crohn's would not eat any processed foods that contain emulsifiers,find toothpaste without detergent,,double rinse dishes.
I have UC but there is a good chance that all the emulsifiers we ingest cause a problem with bacterial translocation in the gut.
It is difficult to tell if any or how much emulsifier makes it through digestion,but it does not take much to lower surface tension.
Here is a list of food emulsifiers from europe,in the USA they may use some different ones.

I looked into this a year or so ago, it was a good idea then as it is now.

Old Mike
Regarding broccoli, I am about 3 years eat on the dinner boiled broccoli! And the result - nothing! yes it is nice but for my CD nothing!
Broccoli and plantain could fight Crohn's disease

About 120,000 people in Britain suffer from the bowel disorder, in which the intestines can become painfully inflamed, causing diarrhoea, vomiting and weight loss.
Now scientists have found that certain types of soluble fibre can help prevent bacteria from sticking to the gut's walls, and hence reduce the progress of the disease.
They found soluable fibre from plantain and broccoli - dubbed a 'superfood' for its abilities to fight cancer and prevent furring of arteries - had a marked effect. However, soluble fibre from leeks and apples did not.
Prof Jonathan Rhodes, a gastroenterologist at Liverpool University, led the laboratory study, the results of which are published today (THUR) in the British Medical Journal.
He and his team added a common type of E coli bacteria to lab-grown bowel lining 'microfold' cells, then tested them with soluble fibre from different fruits and vegetables.
Prof Thodes said: "Soluble fibre might have a beneficial effect by blocking adhesion to the intestinal lining of potentially harmful bacteria."
A clinical study looking at the effect in people is now underway, but Prof Rhodes thought those with the condition "would probably have to eat at least one large plantain each day" to see an effect.
Bananas, from the same family and more commonly available, were also likely to be beneficial. However, Prof Rhodes said they contained less soluble fibre so people would have to consume more.
No work has yet been done on how much broccoli would be needed, but Prof Rhodes said: "I suspect it is rather more than people would want to eat."
He stressed that it was certain types of soluble fibre that had an effect: fibrous material like corn on the cob can worsen Crohn's disease by damaging the gut lining.

What Is E. Coli? (Escherichia Coli)

Researchers Exploring 'Fusion Strategy' Against E-coli
Translocation of Crohn's disease Escherichia coli across M-cells: contrasting effects of soluble plant fibres and emulsifiers

Background Crohn's disease is common in developed nations where the typical diet is low in fibre and high in processed food. Primary lesions overlie Peyer's patches and colonic lymphoid follicles where bacterial invasion through M-cells occurs. We have assessed the effect of soluble non-starch polysaccharide (NSP) and food emulsifiers on translocation of Escherichia coli across M-cells.

Methods To assess effects of soluble plant fibres and food emulsifiers on translocation of mucosa-associated E coli isolates from Crohn's disease patients and from non-Crohn's controls, we used M-cell monolayers, generated by co-culture of Caco2-cl1 and Raji B cells, and human Peyer's patches mounted in Ussing chambers.

Results E coli translocation increased across M-cells compared to parent Caco2-cl1 monocultures; 15.8-fold (IQR 6.2–32.0) for Crohn's disease E coli (N=8) and 6.7-fold (IQR 3.7–21.0) for control isolates (N=5). Electron microscopy confirmed E coli within M-cells. Plantain and broccoli NSP markedly reduced E coli translocation across M-cells at 5 mg/ml (range 45.3–82.6% inhibition, p<0.01); apple and leek NSP had no significant effect. Polysorbate-80, 0.01% vol/vol, increased E coli translocation through Caco2-cl1 monolayers 59-fold (p<0.05) and, at higher concentrations, increased translocation across M-cells. Similarly, E coli translocation across human Peyer's patches was reduced 45±7% by soluble plantain NSP (5 mg/ml) and increased 2-fold by polysorbate-80 (0.1% vol/vol).

Conclusions Translocation of E coli across M-cells is reduced by soluble plant fibres, particularly plantain and broccoli, but increased by the emulsifier Polysorbate-80. These effects occur at relevant concentrations and may contribute to the impact of dietary factors on Crohn's disease pathogenesis.
For the broccoli you would need to eat a truck full though I remember from the author who wrote the initial article. Plantain on the other hand is more potent and eating a banana a day (plantain) should have some effect.

Vitamin A and D both work against MAP in vitro, they are actually really powerful against MAP, I assume they would work on AIEC too, since AIEC are similar to MAP, they're both "trojan horses" as one article put it, they play tricks on the immune system by hiding and reproducing inside a macrophage.

Anything that boosts the immune system, antibiotics and lactic acid bacteria to protect the mucosa help against AIEC. AIEC hide deep in mucosa, they find them in deep layers of the intestine, and they stick there and cause inflammation.