The inflammation in crohn's disease doesn't happen in the lumen you see, it hapens in the lamina propria, the inflammation starts when bacteria enter the lamina propria and tissue macrophages respond (as they should).
This is why the inflammation in crohn's disease is transmural, can causse fistula, and doesn't just subside quickly.
Crohn's is not like UC, Crohn's disease is all about macrophages that live deeper into tissue, and respond to invasive pathogens.
That's why crohn's disease patients experience these deep pains during inflammation, it's the tissue macrophage releasing cytokine that cause the pain.
The macrophages don't just release inflammatory cytokine, they also activate pain mechanics, nociceptors, that's why the pain in crohn's disease feels like tissue, the intestine itself that hurts, it,s the macrophages setting off the alarm bells, in response to invading pathogens.
UC is about the superficial mucosa and neutrophil response.
Macrophages live much longer than neutrophils, that's why crohn's disease is so chronic, takes such a long time of treatment to get mucosal healing etc.
Crohn's is nothing at all like UC, but I have said this a million times, IBD is a horrible horrible word that should not be used.
Crohn's is deep tissue inflammation with granuloma, UC is mucosal inflammation...calling them ''Inflammatory Bowel Disease''...is idiotic, because the inflammatory mechanics behind them are completely different. Crohn's is far more like chronic granulomatous disease, crohn's could easily be called intestinal chronic granulomatous disease, or chronic granulomatous enteritis.