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Normal calprotein and Chrons disease.

My daughter havent been well the last 2 years. Her platelets are to high, nausea ,low back pain, tired an last year she had blood in her stool but no diarrea, Her calprotein was normal. I have now sent her to a private spesialist since the other doctor says as long calprotein is normal its nothing to worry about. Is it possible to have Chrons with normal calprotein and no diarrea?
 

my little penguin

Moderator
Staff member
When my child (adult now ) was dx at age 7.
He did not have diarrhea at all.
Only constipation plus other symptoms including periodic vomiting and slow weight gain /weight loss.
No one suspected crohns but a colonoscopy and upper endoscopy proved on biopsy that he had crohns .

I am not saying your daughter has crohns but there can be a lot going on in the GI tract that can cause issues .
Has she had any scopes /imaging ?
 
When my child (adult now ) was dx at age 7.
He did not have diarrhea at all.
Only constipation plus other symptoms including periodic vomiting and slow weight gain /weight loss.
No one suspected crohns but a colonoscopy and upper endoscopy proved on biopsy that he had crohns .

I am not saying your daughter has crohns but there can be a lot going on in the GI tract that can cause issues .
Has she had any scopes /imaging ?
No but she will meet her new doctor(spesialist) wednesday and I hope he will do someting more to find what this can be. Last year she also loosed weight and had blood in her stool for 3 months.
 
My daughter havent been well the last 2 years. Her platelets are to high, nausea ,low back pain, tired an last year she had blood in her stool but no diarrea, Her calprotein was normal. I have now sent her to a private spesialist since the other doctor says as long calprotein is normal its nothing to worry about. Is it possible to have Chrons with normal calprotein and no diarrea?
The 5 signs of chrons are
- Inflammatory markers (calprotectin or blood)
- Pain
- Blood in the stool (darker coloured usually)
- Uncontrollable weight loss
- Diarrhrea

Any of these could be a sign of chrons
 

kiny

Well-known member
Crohn's Disease onset is quite eventful and acute for many, I would say most. People often have vomiting, fevers, night sweats, aphthous ulcers in the mouth are very common, raised CRP and calprotectin. Often onset is preceded by a foodborne infection and subsequent antibiotics use.

Your doctor telling you not to worry about it when he sees no inflammation or other signs is quite normal on his part. Back pain isn't related to crohn's disease. There's not much one can do when there's no inflammation, colonscopy will likely show nothing, and a histologist will likely find nothing on the biopsy. Even if they could find minor inflammation, some people have idiopathic enteritis that can't be easily explained.
 
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Crohn's Disease onset is quite eventful and acute for many, I would say most. People often have vomiting, fevers, night sweats, aphthous ulcers in the mouth are very common, raised CRP and calprotectin. Often onset is preceded by a foodborne infection and subsequent antibiotics use.

Your doctor telling you not to worry about it when he sees no inflammation or other signs is quite normal on his part. Back pain isn't related to crohn's disease. There's not much one can do when there's no inflammation, colonscopy will likely show nothing, and a histologist will likely find nothing on the biopsy. Even if they could find minor inflammation, some people have idiopathic enteritis that can't be easily explained.
So elevated platelets has nothing to do with inflammation?
 

kiny

Well-known member
No, but it's not a marker for crohn's disease, elevated platelet count is seen in gastrointenstinal infections too. It's not useful as a diagnostic tool.

Blood tests that are useful as diagnostic tools for crohn's disease are CRP, ASCA and Anti-OmpC. But none of them are conclusive, visual inspection with colonoscopy and biopsy with staining are required to give a diagnosis. Things a GI won't recommend unless there is systemic inflammation present (CRP and/or high calprotectin).

Foodborne infections and transient inflammation deemed idiopathic is far too common to draw any conclusions based just on CRP or calprotectin.
 
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No, but it's not a marker for crohn's disease, elevated platelet count is seen in gastrointenstinal infections too. It's not useful as a diagnostic tool.

Blood tests that are useful as diagnostic tools for crohn's disease are CRP, ASCA and Anti-OmpC. But none of them are conclusive, visual inspection with colonoscopy and biopsy with staining are required to give a diagnosis. Things a GI won't recommend unless there is systemic inflammation present (CRP and/or high calprotectin).

Foodborne infections and transient inflammation deemed idiopathic is far too common to draw any conclusions based just on CRP or calprotectin.
 
No, but it's not a marker for crohn's disease, elevated platelet count is seen in gastrointenstinal infections too. It's not useful as a diagnostic tool.

Blood tests that are useful as diagnostic tools for crohn's disease are CRP, ASCA and Anti-OmpC. But none of them are conclusive, visual inspection with colonoscopy and biopsy with staining are required to give a diagnosis. Things a GI won't recommend unless there is systemic inflammation present (CRP and/or high calprotectin).

Foodborne infections and transient inflammation deemed idiopathic is far too common to draw any conclusions based just on CRP or calprotectin.
Ok. so if CRP and calprotein is normal its not Chrons?
 

kiny

Well-known member
It's unlikely. Inflammation in crohn's disease is systemic, it's deep transmural inflammation visible on MRI, the inflammaiton draws in neutrophils into tisue, which is what calprotectin test are able to measure.
 
Thank you for information
Have you had her checked for nutritional deficiencies? Some of these can definitely be caused by that, might be caused by the major issue and if you remove them narrow down the symptoms helping an easier diagnosis. I know platelet count is linked to vitamin K
 
Yes she is checked for everything. Only platelets high ,long time low back pain and nausea. I found some information on the net that some people with chrons have back pain. She talked with a gatrolog and he said she should talk to a hematalog first and then if he didnt find a reason she should come back.
 
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