I had a small bowel resection and ileocoecal valve removal in Dec. 12. I cannot take imuran as I do not synthesize the drug. I have been in what I call a flare for about 2 weeks but dr. did blood and stool sample for c. diff. It was negative. They wanted another stool sample to rule out other bacteria, etc. I don't think they will find anything but I am not in remission and I am flaring. Even after my surgery, I knew I was not in remission. I know that some people on here have achieved remission when they had surgery. My dr. said they would try prednisone again and then maybe biologics, etc. I don't think I can handle pred again. I took it for 5 1/2 months last year and I had every side effect known. I don't want to do it again. I also am not of the mindset to watch/wait/let's see. I do not want another surgery like this for as long as I can possibly keep from having one.I have two questions: Why are some dr.s so afraid of trying biologics/ immunosuppressors? Will taking humira or cimzia, etc. get rid of symptoms like massive diahhrea/joint pain/exhaustion, etc? Thanks for any feedback. I am still waiting on 2nd stool sample and bloodwork by Mon.