I was on 4 G (8 x 500mg) of 5-ASA every day for 7 years. Absolutely no evidence it did anything positive for me... it discolored my urine, it gave me GERD, it caused migraines, and leg cramps. I was AMAZED how much better I felt after coming off that drug entirely.
Zero adverse effect from coming off it. All my side effects went away, and stayed away.
Now, as for enema's... Years ago I was on high steroidal enemas. Most painful treatment ever. gut wrenching... 45 days (eer, nights of it).. but it put me in remission that lasted years... I was undiagnosed at the time, the enemas made everything go away... and I didn't give it a thought until after it all came back to bite me in the proverbial.... My understanding is... direct application this way ensures less side effects.