So, i had to go on prednisone (currently on remicade aswell) back in may month, started on 50 mg/day for seven days, and honestly didn't have a great response. I think things did improve, but definitely not remision like, still had symptoms? Saw my specialist, he insisted I try another dose of 40mg x 1 week, with a five mg taper per week untill finished. Again, poor response, symptoms improved but still dealing with pain, small amounts of blood, and 4-5 times a day. So I was almost tapered off, and I had a camping trip planned and things were getting worse, 7-8 times in the morning with blood and pain, so I thought, I'll do the 40 mg prednisone untill I get home, at least it will be somewhat better. First day I went back to 40mg, I suddenly am normal again. Normal stool, no blood, no pain, once a day kinda thing. So great! now I'm tapered to 5mg again, tomorow will be my last day. But now I have a colonoscopy booked for August (Doc refused to up my remicade untill he could look at my colon), but things feel normal. Hopefully it holds. But why wouldn't the pred work initially?? strange, anybody ever have that happen??