I am in the middle of a flare and have been on 40mg prednisone for the past four days. I can definitely tell a difference but it seems the effect wears off by the early morning right before I take my next dose. I've been taking it with breakfast, around 630/7. But I feel the symptoms coming back at around 4am and they don't subside until about 830am. Then I'm fine the rest of the day. Has anyone else experienced this? Should I try splitting the dose and taking half later so that its in my system longer? I don't want it to interfere with my sleep. I'm also wondering if maybe it will just get better on its own because I'm always worst in the morning anyway so maybe it's the last thing to get better?