Im on Humira and my cycles are horrible , despite being on birth control. My GI dr. said that it was due tothinning of the blood caused by Humira. I also bruise extremely easy since I have been on Humira. Prednisone is the devil. Not only does it make you jittery, but it depletes your bones of Calcium. It really has affected my teeth. I recently had 3 pulled and Im only 30, so I would like to keep my teeth. Entocort is another steroid used for crohn's that doesn't have all of the negative side effects. I was on Remicade for about a year, but it didnt work for me. Maybe one day a drug with no side effects will be created. I wish.. What I can say is that the side effects of these drugs are far better than the flares . Good luck! Kim