My GI doubled my 6MP, upped my sulfasalazine, and restarted my prednisone, because I was so sick on my last visit. I had lost 10 more pounds too. After doing what he prescribed for two weeks, I had lost 3 more pounds, and could barely do anything, I was so nauseous. I quit taking the 6MP, sulfasalazine and prednisone Friday. (I referenced this in a couple of posts, so sorry for redundancy!) I am going to rheumatologist for biologics on May 6th. I just can't stand to be so sick all the time! I have gained those 3 pounds back. What do you think?