I had peripheral neuropathy five years ago from Flagyl. It has progressively gotten better, and was only on the bottoms of my feet. I had my Remicade infusion yesterday, been on it for over two years. This morning my feet and ankles are numb and tingling. I. Do. Not. Need. This. It had been working so great, and the thought of having to go off it is really upsetting. I will have to try and get in to see my GI, but he's always booked solid. Those of you that have had to stop Remicade, did you go into a flare right away? I'm not dealing with this very well at the moment. :depressed: