My son is 15 and we had to make the Remicade decision right after diagnosis. I'm so sorry your son is not doing well with the current treatment. The studies I read and from what my GI said the scariest risk hasn't been substantiated with Remicade alone but when it is used in combination with I belive 6mp or Imuran I could be mistaken on the combo drug but even then when both are used the risk is only slightly higher than that of the general public getting hepatosplenic t cell lymphoma. There is actually a thread on here where you can see the statistics compared. I would recommend researching all you can on credible site, writing down all your anxieties and questions and going over them with the GI. Also there is a Remicade subforum here that you can browse. I will tell you that the Remicade has done wonders for my son and we have seen him improve so much. Sending good thoughts your way! Btw this forum is great for support and information, check out the parents of kids with IBD sub forum, wealth of info there!