Regarding natalizumab, many people with crohn's disease died on those trials, you'll need access to those papers but I've read them, it caused many deaths.
FDA had to pull the drug for crohn's disease because they had many hospitals reporting deaths on their trials. Same thing happened in Europe, many state hospitals had deaths and they pulled the drug for crohn's disease.
Vedolizumab is the derivative of natalizumab and they claim it's safer, I don't believe it for one bit.
The fact GI are willing to ignore cannabis for their patients becaus of "side effects" but have no issues running trials and having multiple people dying in their hospitals on their watch is completely and utterly beyond my comprehension.
Deaths related to crohn's disease have not gone down, they have stayed the same throughout decades, and part of the equation is deaths from drugs that are much higher than they used to be.
I really couldn't believe when some GI started talking about the top-down approach, luckily some have come back from that idea, you can not leave patients on those drugs for years. I truly thought they lost it when they started saying how wonderful the top-down approach would be for patients. This was also at a time when they were using combo therapy, which thank God they have stopped doing now.