• Welcome to Crohn's Forum, a support group for people with all forms of IBD. While this community is not a substitute for doctor's advice and we cannot treat or diagnose, we find being able to communicate with others who have IBD is invaluable as we navigate our struggles and celebrate our successes. We invite you to join us.

Skyrizi Beats Stelara in Several Key Factors in Head-to-Head Comparison Trial

This is wonderful news! When will it be approved for peds?
I figure that will take at least 5 to 10 years. And even for adults, they're going to be required to fail an anti-TNF and probably another biologic before they'll be allowed to get Skyrizi.
 

my little penguin

Moderator
Staff member
Agreed -Peds is typically 5 years after adults
That said if the “child “ is 12 or over most ped Gi will use the drug if a lot of other drugs failed.
Since it’s also trying to psoriasis/PsA watch for adolescent approval there
Then it’s easier to get for the over 12 crowd with crohns
 
I see this in H's near future. It's interesting it works well after Stelara which also tackles the Il-23 pathway along with the Il-12. I wonder why?
 

Scipio

Well-known member
Location
San Diego
It's interesting it works well after Stelara which also tackles the Il-23 pathway along with the Il-12. I wonder why?
Skyrizi probably works after Stelara failure because the Stelara failure was due to the development of antibodies to the Stelara that do not cross-react with the Skyrizi molecule. Much the same thing often happens when Humira works after Remicade failure (or vice versa) even though both drugs target TNF.

Stelara is rather less immunogenic than the older dugs such as Remicade and Humira, but anti-drug antibodies can and do still form in some patients.
 
I figure that will take at least 5 to 10 years. And even for adults, they're going to be required to fail an anti-TNF and probably another biologic before they'll be allowed to get Skyrizi.
Hello,

I am reading through these past discussions on Skyrizi because that is the biologic that my doctor started me on. I'm confused by what you said though. I was newly diagnosed earlier this year (took a little while to determine I had Crohn's) but my doctor started me directly on Skryizi. I had never been on any other biologic before let alone failed one. One time I was prescribed an 8 week taper of a steroid but that is it. Wonder why and how I was able to get on Skyrizi? I also wonder if I fail Skyrizi if that means the other ones won't work for me because I started on Skyrizi. I'm newly diagnosed so I feel very in the dark mostly.
 
I think that GI's have a typical pattern for biologics based on what has been used the longest and had the most evidence supporting it's probability for inducing remission.
There isn't anything wrong with your doctor starting you on Skyrizi, and if it stops working he may very well try you on a drug like Remicade or Humira.
I think people who have had Crohn's for awhile are just used to the pattern we see of anti-tnf drugs first, then Entyvio or Stelara and then whatever else drug.
Hopefully Skyrizi is the right one for you! There is a bit of trial and error that goes into choosing a drug, and some drugs you may lose response to or build antibodies to - even if they previously work for years.
 
I should add that insurance coverage can play a part in drug selection because sometimes your insurer will want to see certain drugs tried first before they will pay for coverage on more expensive medications.
 
I should add that insurance coverage can play a part in drug selection because sometimes your insurer will want to see certain drugs tried first before they will pay for coverage on more expensive medications.

Okay, good. Thank you for this explanation.

Hopefully Skyrizi works for me and that I am able to be on it for a long time . I have seen improvement. But, I am not my pre-Crohn's self. I have been on it since April and go in soon for a push enteroscopy and vce which will tell me more. Thank you again for your reply.
 
Hello,

I am reading through these past discussions on Skyrizi because that is the biologic that my doctor started me on. I'm confused by what you said though. I was newly diagnosed earlier this year (took a little while to determine I had Crohn's) but my doctor started me directly on Skryizi. I had never been on any other biologic before let alone failed one. One time I was prescribed an 8 week taper of a steroid but that is it. Wonder why and how I was able to get on Skyrizi? I also wonder if I fail Skyrizi if that means the other ones won't work for me because I started on Skyrizi. I'm newly diagnosed so I feel very in the dark mostly.
I'm just referring to insurance requirements and common prescribing patterns. These things take years to change. You're lucky that you've been allowed to get Skyrizi first.
 
I'm just referring to insurance requirements and common prescribing patterns. These things take years to change. You're lucky that you've been allowed to get Skyrizi first.

Okay, thanks. Since I am newly diagnosed, I don't know what the standard treatment guidelines are. Yes, I guess I am fortunate. If Skyrizi ends up working for me. I am anxious to see the results of my upcoming push enteroscopy. Thank you for replying!
 
Top