Anybody familiar with Skyrizi? Stelara was dropped from my insurance company's formulary and there's murmurings about switching me to Skyrizi. Apparently it targets the protein IL-23 as does Stelara. But Stelara targets both IL-12 and IL-23
I have no experience with Skyrizi, but in theory it should work very similarly to Stelara. As you point out, they both act by binding and inhibiting the immune-activating protein IL-23. And based on a lot of research into the mechanisms, IL-23 is thought to be the key protein in question here. IL-12 is sort of "along for the ride" so to speak. Blocking IL-23 is doing the heavy lifting in controlling the overactive immune response of IBD and autoimmune diseases.Anybody familiar with Skyrizi? Stelara was dropped from my insurance company's formulary and there's murmurings about switching me to Skyrizi. Apparently it targets the protein IL-23 as does Stelara. But Stelara targets both IL-12 and IL-23
The patient may have developed antibodies against Stelara that block its action (although this isn't very common, it does occur), and Skyrizi avoids this because it is a different protein.An IBD doctor we consulted with said that Skyrizi can be successful even with people that Stelara didn't help. I was surprised to learn this and I'm not sure why this would be - it all seems to be very complicated.
I really like your analogy of Crohn's having different personalities as humans. Some fight hard, some not so much, some prefer certain foods, some back away mysteriously, some are full of energy and life. This is great. I am gonna ask the researchers which one we should take on first.Skyrizi is working great for me right now.
With my past doctors, wanting me to be on Stelara from the beginning, I suspect many of my other drugs were working too, but when I got C-Diff 6 times, it didn't matter what drug I was on, I flared. When a close family member or friend passed away, I flared. It seems that my former doctors sort of wanted me to fail up to getting Stelara approved by insurance, which was a disconnect for what was truly the best course for me.
Now I have a great team and it's about whatever will work best for me. Skyrizi is now the answer. But we will keep our options open as always.
Crohn's and our responses to the different drugs can be as varied is all of our personalities. Crohn's drugs are getting better and hopefully so are all of us are getting going to get better too. I have a pharmacy tech I know who's brother has been on Remicade for many years and it's working just fine. I say, good for him.
Crohn's personalities are just like each one of us and very unique, some a lot more than others.
Whoever you are, you are the very most important and special person that you will always wake up with.
Our, oh so unfortunate companion in life, Crohn's disease, the classic used car guy who takes advantage of whatever he can to close deals, no matter what lowly customers want or need. Crohn's waiting in the dim lit parking lot, ready to strike whenever and wherever it can.
For some of us, it is sometimes like internal swarms of steroid infused mosquitos.
However different we may be, what we have in common is all the more.......