I work in biotech. When my daughter was first diagnosed and put on prednesone she was taking 60 mg every morning. We noticed that her symptoms got worse late in the day. I asked the gastroenterologist if it wouldn't be better for her to take 30 mg in the morning and 30 mg 12 hours later. He agreed that would be better at maintaining a steady dose level. So we switched to that mode. Her symptoms improved and we began to taper down the dose and eventually go back to once a day. We were down to 10 mg once a day disaster stuck: she got a bad head cold which caused a bad flare up. She has been taking 30 mg twice per day, and eating liquid diet, but symptoms still bad. I am wondering whether taking the pred in a single dose is more effective!