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Study may have solved a mystery surrounding Crohn’s disease

@Scipio , @my little penguin , @Maya142 and other moderators & anyone who would like to share their thoughts. There are quite a number of studies all stating different genes as causing Crohn's disease.

https://www.sciencedaily.com/releases/2018/09/180918110948.htm - RNF5 gene

https://www.sciencedaily.com/releases/2022/12/221201123138.htm - gene AGR2

https://www.hindawi.com/journals/dm/2012/340204/ - PTPN2 gene

- Norovirus and protein API5

What confuses me is that each of the above studies came up with a different gene or a different cause? While I understand that Crohn's disease is incredibly complex but still there should be some commonality which is missing. Let me know your thoughts.
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my little penguin

Staff member
Crohns is a gigantic umbrella term for multiple phenotypes of similar disease patterns imo
Infantile crohns is vastly different than very early onset crohns and those differ from pediatric crohns .
That only makes up 10% of crohns cases
Adult crohns as well has 3-4 phenotypes which behave differently and respond differently to different types of meds
Studies on genetics and what genes cause what in crohns change every few years
At least in the past 12 years my kiddo has been dealing with it

Basically they need better subsets similar to juvenile arthritis
One umbrella term but many subtypes with different names and treatments