I recall nicotine from tobacco interacts with these pathways, and I found a study of nicotine patches used to treat U.C. and it seemed to helped more patients reach remission.Recent data have shown that the anti-inflammatory properties of the vagus nerve also involve peripheral efferents via an interaction of acetylcholine with nicotinic receptors leading to an inhibition of TNF release by macrophages
wow, super interesting! thanks! Its coming for us I am positive!!!
https://spectrum.ieee.org/the-human-os/biomedical/devices/vagus-nerve-stimulation-takes-on-crohns-diseaseSo far, the trial is going well, according to SetPoint, which this week released preliminary results. Of the 16 people who participated, half of the them experienced clinically meaningful improvements in typical Crohn’s disease symptoms—the kind of improvements that will enable them to leave the house, be in less pain, and avoid hospitalizations, according to SetPoint. Four of the subjects experienced remission, meaning they had minimal residual disease.