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The Crohn’s Disease Exclusion Diet (CDED): A Comprehensive Review

kiny

Well-known member
I think the positive data for CDED has been weak so far. While CDED is more restrictive, previous studies where a 50% EN and 50% free diet was tried failed.

Still, the idea of only having to consume 50% EN combined with a less restrictive diet is appealing to increase compliance with patients. EN studies are cheap and there are plenty patients willing to try a diet to relieve symptoms, many more studies are being done. This is a good overview so far.

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CDED did NOT work for us. Calpro went from 500-2200 in 3 months - but interestingly it did completely clear a small patch of psoriasis that has never returned.
 

kiny

Well-known member
There was a new study in the UAE that showed very low compliance with CDED / EN.

Only 40% of patients could maintain the diet for more than 3 months.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10515460/pdf/cureus-0015-00000043970.pdf

Out of the total, 84% of the cohort utilized the CDED, while 16% used EEN.

(3%) could only follow the diet plan for a few days
(19%) were able to follow the plan for one and two months
(40%) were able to follow the diet plan for more than three months
(19%) of patients were able to continue the diet plan for more than one year
The biggest factor for failing the diet was intolerance and difficulty to follow. Other factors were high cost and difficulty to prepare the meals.

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It's not that surprising when I think about it. I have been using EN for longer than I can count. If I was allowed to eat 50% of my calories through solid foods, I would surely not maintain my compliance with EN, because cravings for solid foods would return.

The big selling point of CDED is compliance, if it can not increase compliance it is pointless.

The remission data on CDED is still far too weak (I noticed the other day that one study on CDED+EN had abnormally low remission rates for exclusive EN. EN remission rates are generally 80%-90% after 8 weeks, higher in ileal patients. This study had too low remission rates on EEN, which makes me question the compliance of the study subjects and the positive CDED conclusions.).
 
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