I have been on Humira for the past 18 months. This is in addition to 150 mg of Imuran daily. Although I have seen some improvement in my symptoms, it has not been the wonder drug for me that it has for some. My last colonoscopy still showed inflammation and friable tissue with lots of bleeding, although it was much improved from the year prior. (Still had lots of inflammation and bleeding after being on Humira and Imuran for a little over a year.) Within 3 months of starting the Humira, I caught a cold that turned into a severe sinus infection that took nearly 3 months and multiple rounds of antibiotics to get rid of. Since starting Humira, I have had multiple infections, everything from sinus infections to bronchitis to UTI, etc, that's not even counting all the yeast infections. I have had to be treated with antibiotics for 6 infections in the last year. Currently I am battling another sinus infection and have just broken out with shingles. This is my ninth (that's right, ninth) bout of shingles since 2003, when I started Imuran. I have missed my last 3 Humira injections because of all these infections. I lost my spleen in 2003 due to another autoimmune blood condition, so all these infections concern me greatly since the spleen is such a major player in the immune system. I am so frustrated right now. I feel like I am getting no direction from my medical professionals. My GP says that Humira use scares her. My GI says he will leave it up to me wheter to continue it, but seems really indifferent about it. I see my hematologist next week and will ask for guidance from her. I am really at my wits end about whether to stop the Humira or continue it. All these infections are wearing me out. I really don't know what drugs to turn to either. I have tried prednisone, flagyl, Asacol, Remicade, rowasa enemas, you name it. I've just about exhausted any pharmaceutical routes. Any thoughts, suggestions, recommendations, etc. would really help me. I am so mentally and physically tired. Thanks:sign0085:!