I had my first resection in 2001. My surgeon said my bowel had perforated several times, and he was not sore how i was alive. I had my second resection in 2009, and later in the year had a hernia surgery. Earlier this year i had my third resection, and ended up with an enterocutaneous fistula which required another resction and has healed. I have been on asacol, methotrexate, Remicadee, humira, enbrel, cimzia, symponi, and imuran. I amnow being treated at the university level, and i am lucky enough to have one of the leading universities in my home town. They want to start me on tysabri, and i am really nervous! Has anyone been on this? I can tell i am starting to obstruct again, and now have a rectovag fistula, so thi.gs are.t going well, even though my symponi is now at 100 mgs. I have always been very active, i lead a girls scout troop, am a hospice nurse, have 2 kids, and am a generally positive person. For the first time, i feel like this is beating me